新娘（乌玛·瑟曼 Uma Thurman 饰）曾是暗杀组织中的一名成员，也是组织首脑比尔（大卫·卡拉丁 David Carradine 饰）的情人，金盆洗手后的她结识了一个单纯的小伙子并准备忘掉过去与之结婚。没想到，婚礼当天比尔突然出现，并带领手下大开杀戒，霎时间，圣洁 的教堂变成人间地狱。新娘头部中弹昏迷4年，醒来后脑中首先想起的便是昏迷眼前的几张残酷的面孔，“黑曼巴”、“蝮蛇”、“百步蛇”、“加州山蛇”和比尔，他们是曾经的同僚和爱人，是如今的敌人。满腔怒火的新娘要一一的找到她们，不问是非对错，赶尽杀绝。

　　Colonel Branson (Thomas Gibson), head of a secret and covert division of the NSA, keeps the Shadow Wolves operating albeit now independent and rogue. His anger after his daughter was killed in Afghanistan training civilians drives him to defend "his" America and her borders by all means legal or otherwise. When ISIS terrorists begin to sneak across the US Border into Arizona, Branson alerts the Shadow Wolves to track and stop them. Branson sends Eric Shaw (Cody Walker), his most deadly and effective agent, to join up with the Shadow Wolves. The Wolves are led by Nabahe (Graham Greene), a Navajo honored military veteran, and an old colleague of Branson's. At the same time in London Lady Milton-Simon (Louise Lombard), head of an MI6 anti-terrorist division, sends out her elite agent, Major McLaren (Tom Hutch), to track a terrorist named Khan (Solomon Shiv) who has a personal vendetta against the US and the Shadow Wolves. Lady Milton and McLaren learn Khan is heading to Mexico to be ...